2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-139052
    III-31-C 398515-96-3 98%
    III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits Aऔ production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research.
    III-31-C
  • HY-139088
    PAD3-IN-1 1671088-84-8 98%
    PAD3-IN-1 (compound 14b) is an inhibitor of protein arginine deiminase (PAD) and is more than 10-fold more selective for PAD3 than PAD 1, 2, and 4. The IC50 values ​​of PAD3-IN-1 for PAD 1, 2, 3, and 4 are 120, 27.5, 4.5, and 30.5 μM, respectively. And PAD3 is a PAD isoform associated with neurodegenerative responses to spinal cord injury, and PAD3-IN-1 could be used to study PAD-related neurological diseases.
    PAD3-IN-1
  • HY-139126
    (±)-Muscarine chloride 2936-25-6 98%
    (±)-Muscarine chloride is the racemate of Muscarine chloride. Muscarine is a prototype muscarinic acetylcholine receptor agonist.
    (±)-Muscarine chloride
  • HY-139144
    YM-08 812647-88-4 98%
    YM-08 (Compounds 7a) is a brain-penetrant inhibitors of SIRT2,with the IC50 of 19.9 μM. YM-08 also is inhibitor of Hsp70.
    YM-08
  • HY-139145
    Etbicyphat 1005-93-2 98.0%
    Etbicyphat (Trimethylopropane phosphate) is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors.
    Etbicyphat
  • HY-139233
    25P-NBOMe hydrochloride 1539266-43-7 98%
    25P-NBOMe hydrochloride is structurally categorized as a phenethylamine. 25P-NBOMe hydrochloride binds 5-HT receptors 5-HT2A and 5-HT2C with similar affinities.
    25P-NBOMe hydrochloride
  • HY-139246
    α-Pyrrolidinocyclohexanophenone hydrochloride 1803168-16-2 98%
    α-Pyrrolidinocyclohexanophenone hydrochloride is a drug derivative.
    α-Pyrrolidinocyclohexanophenone hydrochloride
  • HY-13929R
    Isocarboxazid (Standard) 59-63-2
    Isocarboxazid (Standard) is the analytical standard of Isocarboxazid. This product is intended for research and analytical applications. Isocarboxazid is a non-selective and irreversible inhibitor of monoamine oxidase, with an IC50 of 4.8 μM for rat brain monoamine oxidase in vitro.
    Isocarboxazid (Standard)
  • HY-139350
    AMPA receptor antagonist-1 923271-87-8 98%
    AMPA receptor antagonist-1 (Example 143) is an AMPA receptor antagonist. AMPA receptor antagonist-1 can be used in the research of neurological disorders.
    AMPA receptor antagonist-1
  • HY-139359
    4-Fluoro pentedrone hydrochloride 2469350-88-5 98%
    4-Fluoro pentedrone hydrochloride is a drug derivative.
    4-Fluoro pentedrone hydrochloride
  • HY-139360
    MDPT(tBuONE) 2469270-98-0 98%
    3',4'-Methylenedioxy-N-tert-butylcathinone hydrochloride is structurally categorized as a drug derivative.
    MDPT(tBuONE)
  • HY-139377
    4-Methoxy-α-pyrrolidinopropiophenone hydrochloride 1794760-01-2 98%
    4-Methoxy-α-pyrrolidinopropiophenone hydrochloride is a biomolecule.
    4-Methoxy-α-pyrrolidinopropiophenone hydrochloride
  • HY-139388
    Para-fluoro methylaminorex 1364933-64-1 98%
    Para-fluoro methylaminorex is a neuroactive compound.
    Para-fluoro methylaminorex
  • HY-139406
    1,2-Dioctanoyl-sn-glycero-3-phospho-1'-myo-inositol-4'-phosphate ammonium 1246303-11-6 98%
    1,2-Dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-4'-phosphate) (PtdIns-(4)-P1 (1,2-dioctanoyl)) ammonium is a synthetic phosphatidylinositol. 1,2-Dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-4'-phosphate) ammonium can be used for the research of signal transduction research.
    1,2-Dioctanoyl-sn-glycero-3-phospho-1'-myo-inositol-4'-phosphate ammonium
  • HY-139568
    Deutarserine 103292-62-2 98%
    Deutarserine is a deuterium modified analog of endogenous D-serine (CTP 692), which is used in the research of adults with schizophrenia.
    Deutarserine
  • HY-13956C
    (R)-Pioglitazone 959687-65-1 98%
    (R)-Pioglitazone ((+)-pioglitazone) is the R enantiomer of Pioglitazone (HY-13956). (R)-Pioglitazone is an orally active and selective peroxisome proliferator-activated receptor (PPARγ) agonist with high affinity binding to the PPARγ ligand-binding domain. (R)-Pioglitazone can be used for the research of Alzheimer's disease.
    (R)-Pioglitazone
  • HY-139629
    ANAT inhibitor-1 331751-78-1 98%
    ANAT inhibitor-1 is a human aspartate N-acetyltransferase (ANAT) inhibitor for canavan disease.
    ANAT inhibitor-1
  • HY-139677
    5-HT7R antagonist 1 2759919-13-4 98%
    5-HT7R antagonist 1 is a G protein-biased antagonist against 5-HT7R (Ki = 6.5 nM).
    5-HT7R antagonist 1
  • HY-139678
    SC13 2839142-69-5 98%
    SC13 is an orally active, selective Flap structure-specific endonuclease 1 (FEN1) inhibitor and mu opioid receptor (MOR) activator. SC13 impairs DNA damage repair and induces apoptosis in cancer cells. SC13 activates cGAS-STING signaling, increases chemokine secretion, and promotes CAR-T cell infiltration at solid tumour sites. SC13 can be used for the research of solid tumours and pain.
    SC13
  • HY-139680
    Dopamine D3 receptor antagonist-1 3052236-36-6 98%
    Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor-selective or multitarget bitopic ligand (Ki = 1.58 nM) potentially useful for central nervous system disorders.
    Dopamine D3 receptor antagonist-1
Cat. No. Product Name / Synonyms Application Reactivity